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8-Prenylnaringenin

Cat. No. M5173
8-Prenylnaringenin Structure
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5mg USD 300  USD300 1-2 Weeks
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Biological Activity

8-Prenylnaringenin

Chemical Information
Molecular Weight 340.37
Formula C20H20O5
CAS Number 53846-50-7
Solubility (25°C) Methanol
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Corinna Urmann, et al. Semi-Synthetic Approach Leading to 8-Prenylnaringenin and 6-Prenylnaringenin: Optimization of the Microwave-Assisted Demethylation of Xanthohumol Using Design of Experiments

[2] Jin-Bo Fang, et al. Formation of (2 R)- and (2 S)-8-Prenylnaringenin Glucuronides by Human UDP-Glucuronosyltransferases

[3] Judy L Bolton, et al. The Multiple Biological Targets of Hops and Bioactive Compounds

[4] Kateřina Štulkov, et al. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops

[5] Olga Wesołowska, et al. 8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1

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