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8-Hydroxyquinoline

Cat. No. M11307
8-Hydroxyquinoline Structure
Synonym:

8-Oxychinolin, 8-Quinolinol, Oxine

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100mg USD 60  USD60 In stock
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Biological Activity

8-hydroxyquinoline is a mono-proton bicyclic chelator that is used as a preservative, disinfectant, and insecticide and as a transcription inhibitor. It is a preservative with mild fungal, bacterial, repellent and amoeba killing properties. It is a strong copper ion-carrier and can be used in copper death (Cuproptosis) research.

Chemical Information
Molecular Weight 145.16
Formula C9H7NO
CAS Number 148-24-3
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gomes LM, et al. J Inorg Biochem. 8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation.

[2] Anglica Rocha Joaquim, et al. J Med Chem. Novel Antimicrobial 8-Hydroxyquinoline-Based Agents: Current Development, Structure-Activity Relationships, and Perspectives

[3] Avinash Kotian, et al. Bioorg Chem. 8-Hydroxyquinoline derived p-halo N4-phenyl substituted thiosemicarbazones: Crystal structures, spectral characterization and in vitro cytotoxic studies of their Co(III), Ni(II) and Cu(II) complexes

[4] Yutao Jia, et al. Mater Sci Eng C Mater Biol Appl. 8-Hydroxyquinoline functionalized covalent organic framework as a pH sensitive carrier for drug delivery

[5] Nail Moreira da Silva, et al. Med Mycol. 8-Hydroxyquinoline 1,2,3-triazole derivatives with promising and selective antifungal activity

[6] B Pippi, et al. J Appl Microbiol. 8-Hydroxyquinoline-5-sulfonamides are promising antifungal candidates for the topical treatment of dermatomycosis

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Keywords: 8-Hydroxyquinoline, 8-Oxychinolin, 8-Quinolinol, Oxine supplier, Cuproptosis, inhibitors, activators

 
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