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8-Bromo-cAMP sodium salt

Cat. No. M1593
8-Bromo-cAMP sodium salt Structure
Synonym:

8-Br-cAMP sodium salt

Size Price Availability Quantity
10mM*1mL in DMSO USD 55  USD55 In stock
5mg USD 50  USD50 In stock
10mg USD 65  USD65 In stock
50mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator. 8-Bromo-cAMP sodium salt enhances the efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium salt inhibits proliferation, induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109).

Chemical Information
Molecular Weight 430.08
Formula C10H10BrN5NaO6P
CAS Number 76939-46-3
Solubility (25°C) DMSO ≥ 35 mg/mL (Need warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wang Y, et al. Stem Cell Rev Rep. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells.

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Keywords: 8-Bromo-cAMP sodium salt, 8-Br-cAMP sodium salt supplier, PKA, inhibitors, activators


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