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7-Ethylcamptothecin

Cat. No. M7505
7-Ethylcamptothecin Structure
Size Price Availability Quantity
100mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 376.41
Formula C22H20N2O4
CAS Number 78287-27-1
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Practical synthesis of (20S)-10-(3-aminopropyloxy)-7-ethylcamptothecin, a water-soluble analogue of camptothecin.
Watanabe T, et al. Chem Asian J. 2013 Mar; 8(3):630-8. PMID: 23281180.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 7-Ethylcamptothecin supplier, Topoisomerase, inhibitors

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