Free shipping on all orders over $ 500

6H05

Cat. No. M20594
6H05 Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

6H05 is a selective, and allosteric inhibitor of oncogenic K-Ras(G12C).

Chemical Information
Molecular Weight 590.14
Formula C22H31ClF3N3O4S3
CAS Number 2061344-88-3
Solubility (25°C) DMSO 100 mg/mL
Water 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related ROCK Products
Akt/ROCK-IN-1

Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively.

Scaff10-8

Scaff10-8, bound to RhoA, inhibits the AKAP-Lbc-mediated RhoA activation.

ROCK-IN-6

ROCK-IN-6 is a potent and selectiveROCK2 inhibitor with an IC50 of 2.19 nM.

ROCK-IN-4

ROCK-IN-4 is a potent ROCK inhibitor maintaining NO releasing ability.

ROCK-IN-32

ROCK-IN-32 is a ROCK inhibitor, with an IC50 value of 11 nM for ROCK2.

  Catalog
Abmole Inhibitor Catalog




Keywords: 6H05 supplier, ROCK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.