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6-Methylcoumarin

Cat. No. M9031
6-Methylcoumarin Structure
Synonym:

Toncarine

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100mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Transport experiments with Caco-2 cells show that 6-Methylcoumarin presents high permeability at all concentrations evaluated. This finding suggests that 6-Methylcoumarin could be transported across the gut wall by passive diffusion.

The plasma concentration-time curve shows that the maximum concentration (Cmax) is 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route (200 mg/kg) and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration (200 mg/kg), with elimination constant of (Ke) 0.0070/min and a short life half time of (T1/2) lower that 120 min. 6-Methylcoumarin has high accumulation in the liver, and widespread distribution in all the organs evaluated. The oral bioavailability (F) of 6-Methylcoumarin is 45% in Wistar rats.

Chemical Information
Molecular Weight 160.17
Formula C10H8O2
CAS Number 92-48-8
Solubility (25°C) DMSO: ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Toyooka T, et al. J Invest Dermatol. Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity.

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Keywords: 6-Methylcoumarin, Toncarine supplier, inhibitors, activators


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