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6-Mercaptopurine (6-MP) Monohydrate

Cat. No. M5375

6-Mercaptopurine (6-MP) Monohydrate Structure
Size Price Availability Quantity
200mg USD 80 In stock
500mg USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mercaptopurine is widely used to treat malignancies, rheumatic diseases, dermatologic conditions, inflammatory bowel disease, and solid organ transplant rejection. Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase (PRPP Amidotransferase). PRPP Amidotransferase is the rate limiting enzyme of purine synthesis. It alters the synthesis and function of RNA and DNA. Mercaptopurine interferes with nucleotide interconversion and glycoprotein synthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 170.19
Formula C5H6N4OS
CAS Number 6112-76-1
Purity >99%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Improving the dissolution and bioavailability of 6-mercaptopurine via co-crystallization with isonicotinamide.
Wang JR, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1036-9. PMID: 25630224.

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  Catalog
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Keywords: 6-Mercaptopurine (6-MP) Monohydrate supplier, DNA/RNA Synthesis, inhibitors

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