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6-Maleimidohexanoic acid N-hydroxysuccinimide ester

Cat. No. M6213
6-Maleimidohexanoic acid N-hydroxysuccinimide ester Structure
Synonym:

EMCS

Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 280 In stock
100mg USD 425 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 308.29
Formula C14H16N2O6
CAS Number 55750-63-5
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
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  Catalog
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Keywords: 6-Maleimidohexanoic acid N-hydroxysuccinimide ester, EMCS supplier, inhibitors

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