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6-Maleimidocaproic Acid

Cat. No. M6214
6-Maleimidocaproic Acid Structure
Size Price Availability Quantity
50mg USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

A sulfhydryl reactive heterobifunctional crosslinking reagent. Widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 211.215
Formula C10H13NO4
CAS Number 55750-53-3
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Development of albumin-binding camptothecin prodrugs using a Peptide positional scanning library.
Schmid B, et al. Bioconjug Chem. 2007 Nov-Dec;18(6):1786-99. PMID: 17915955.

Synthesis and biological activity of water-soluble maleimide derivatives of the anticancer drug carboplatin designed as albumin-binding prodrugs.
Warnecke A, et al. Bioconjug Chem. 2004 Nov-Dec;15(6):1349-59. PMID: 15546202.

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  Catalog
Abmole Inhibitor Catalog 2017




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