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5α-Pregnan-3α-ol-20-one

Cat. No. M8027
5α-Pregnan-3α-ol-20-one Structure
Synonym:

3α,5α-THP; SAGE-547; Brexanolone

Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 140 In stock
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Quality Control
Biological Activity

Positive allosteric modulator of GABAA chloride channel.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 318.49
Formula C21H34O2
CAS Number 516-54-1
Purity >98%
Solubility DMSO: 4 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 5α-Pregnan-3α-ol-20-one, 3α,5α-THP; SAGE-547; Brexanolone supplier, GABA Receptor, inhibitors

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