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5'-N-Ethylcarboxamidoadenosine

Cat. No. M13885
5'-N-Ethylcarboxamidoadenosine Structure
Synonym:

NECA

Size Price Availability
5mg USD 65  USD65 4-7 Days
10mg USD 90  USD90 4-7 Days
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Quality Control & Documentation
Biological Activity

5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.

Chemical Information
Molecular Weight 308.29
CAS Number 35920-39-9
Solubility (25°C) DMSO 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bhupesh Chandra Semwal, et al. 5-N-ethyl Carboxamidoadenosine Stimulates Adenosine-2b Receptor-Mediated Mitogen-Activated Protein Kinase Pathway to Improve Brain Mitochondrial Function in Amyloid Beta-Induced Cognitive Deficit Mice

[2] Shanshan Liu, et al. 5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor

[3] A Monopoli, et al. Pharmacology of the new selective A2a adenosine receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine

[4] N J Cusack, et al. 5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation

[5] M H Sabouni, et al. Roles of calcium and the endothelium in the relaxations produced by 5'-N-ethylcarboxamidoadenosine (NECA)

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Keywords: 5'-N-Ethylcarboxamidoadenosine, NECA supplier, Adenosine Receptor, inhibitors, activators


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