Free shipping on all orders over $ 500


Cat. No. M7506
5-methoxyflavone Structure


Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. The treatment with 5-methoxyflavone (5-MF) at various times (3, 6, 12, 18 and 24 h) in MOLT-4 cells results in a time dependent reduction in the levels of antiapoptotic proteins cFLIP, Mcl-1 and an increase in the proapoptotic protein BAX. 5-MF induces both TRAIL-R1(DR4) and TRAIL-R2 (DR5) in a time-dependent manner.

Cell Experiment
Cell lines human leukemic MOLT-4, U937 cell lines and PBMCs
Preparation method MOLT-4 or U937 or PBMC cells are treated with DMF or TMF or PMF, 5-MF or 2'-MF at various concentrations for 24 h, then the cell viability is determined by the MTT assay.
Concentrations 0-100 μg/ml
Incubation time 24 h
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 252.26
Formula C16H12O3
CAS Number 42079-78-7
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C

Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity.
Merlo S, et al. J Nat Prod. 2015 Nov 25;78(11):2704-11. PMID: 26517378.

Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines.
Wudtiwai B, et al. J Hematol Oncol. 2011 Dec 21;4:52. PMID: 22185222.

Related DNA/RNA Synthesis Products

COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity.


Plicamycin, also known as mithramycin or Mithramycin A is a n antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity.

GC7 Sulfate

GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

Pyridostatin Trifluoroacetate Salt

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer, with a Kd of 490 nM.

Chebulinic acid

Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

Abmole Inhibitor Catalog 2017

Keywords: 5-methoxyflavone, 5-MF supplier, DNA/RNA Synthesis, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.