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Cat. No. M6291
5-Iodotubercidin Structure

NSC 113939, 5-ITu

Size Price Availability Quantity
10mg USD 200 In stock
25mg USD 440 In stock
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Quality Control
Biological Activity

In vitro: 5-Iodotubercidin(Itu) is a genotoxic drug that activates the Atm-p53 pathway and has anti-tumor activity. Itu is unique compared to other nucleoside analogs in the way that it induces G2 arrest in a p53 -dependent manner. Moreover, at higher doses, Itu might activate p53-independent pathways, which may cooperate with p53 to kill cells and inhibit tumor growth. Incorporation of Itu metabolite into DNA causes DNA breaks, which triggers the DNA damage response. Itu might be a potential chemotherapeutic drug with distinct working mechanisms.

In vivo: 5-Iodotubercidin is a potent inhibitor of adenosine kinase in the rat brain. 5-iodotubercidin has potent hypotensive, muscle relaxant, and hypothermic actions in mice, and that these effects could be blocked by theophylline, an adenosine receptor antagonist. 5-iodotubercidin (1 mg/kg, i.p.) administered prior to an ischemic episode, fails to provide a degree of cerebroprotection, assessed either by locomotor or histopathological indices Even though 5-iodotubercidin administration is known to enhance extracellular adenosine levels in brain slices.

Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Male Mongolian gerbils
Formulation Saline
Dosages 1, 2.5 and 5 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 392.15
Formula C11H13IN4O4
CAS Number 24386-93-4
Purity 100.00%
Solubility 42 mg/mL in DMSO
Storage at -20°C

Inhibitory effect of 5-iodotubercidin on pigmentation.
Kim KI, et al. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1282-1286. PMID: 28684314.

Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential.
Zhang X, et al. PLoS One. 2013 May 7;8(5):e62527. PMID: 23667485.

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Keywords: 5-Iodotubercidin, NSC 113939, 5-ITu supplier, Adrenergic Receptor, inhibitors

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