Free shipping on all orders over $ 500

5-Iodotubercidin

Cat. No. M6291
5-Iodotubercidin Structure
Synonym:

NSC 113939, 5-ITu

Size Price Availability Quantity
10mg USD 200 In stock
25mg USD 440 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In vitro: 5-Iodotubercidin(Itu) is a genotoxic drug that activates the Atm-p53 pathway and has anti-tumor activity. Itu is unique compared to other nucleoside analogs in the way that it induces G2 arrest in a p53 -dependent manner. Moreover, at higher doses, Itu might activate p53-independent pathways, which may cooperate with p53 to kill cells and inhibit tumor growth. Incorporation of Itu metabolite into DNA causes DNA breaks, which triggers the DNA damage response. Itu might be a potential chemotherapeutic drug with distinct working mechanisms.

In vivo: 5-Iodotubercidin is a potent inhibitor of adenosine kinase in the rat brain. 5-iodotubercidin has potent hypotensive, muscle relaxant, and hypothermic actions in mice, and that these effects could be blocked by theophylline, an adenosine receptor antagonist. 5-iodotubercidin (1 mg/kg, i.p.) administered prior to an ischemic episode, fails to provide a degree of cerebroprotection, assessed either by locomotor or histopathological indices Even though 5-iodotubercidin administration is known to enhance extracellular adenosine levels in brain slices.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Mongolian gerbils
Formulation Saline
Dosages 1, 2.5 and 5 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 392.15
Formula C11H13IN4O4
CAS Number 24386-93-4
Purity >98%
Solubility 78 mg/mL in DMSO
Storage at -20°C
References

Inhibitory effect of 5-iodotubercidin on pigmentation.
Kim KI, et al. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1282-1286. PMID: 28684314.

Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential.
Zhang X, et al. PLoS One. 2013 May 7;8(5):e62527. PMID: 23667485.

Related Adrenergic Receptor Products
L-755,507

L-755,507 is a very potent and selective β 3 partial agonist.

Xylometazoline HCl

Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.

Xylazine HCl

Xylazine is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.

Tizanidine HCl

Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

Terazosin HCl

Terazosin is a selective alpha-1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 5-Iodotubercidin, NSC 113939, 5-ITu supplier, Adrenergic Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.