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5-Ethynyl-2'-deoxyuridine

Cat. No. M9791
5-Ethynyl-2'-deoxyuridine Structure
Synonym:

Edu

Size Price Availability Quantity
50mg USD 37  USD37 In stock
100mg USD 64  USD64 In stock
500mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Chemical Information
Molecular Weight 252.22
Formula C11H12N2O5
CAS Number 61135-33-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sainan An, et al. EBioMedicine. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy dvrgs

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  Catalog
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Keywords: 5-Ethynyl-2'-deoxyuridine, Edu supplier, PROTAC Linker, inhibitors, activators


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