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5-Chloropyridazine-3,4-diamine

Cat. No. M9672
5-Chloropyridazine-3,4-diamine Structure
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Biological Activity

5-Chloropyridazine-3,4-diamine

Chemical Information
Molecular Weight 144.56
Formula C4H5ClN4
CAS Number 89123-72-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Moustafa Sherief Moustafa, et al. Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines

[2] Kaliyaperumal Thanigaimani, et al. 6-(4-Meth-oxy-phen-yl)-1,3,5-triazine-2,4-diamine

[3] Jia-Qin Liu, et al. Poly[di-μ(3)-chlorido-di-μ(2)-chlorido-{μ(4)-N,N,N',N'-tetra-kis-[(diphenyl-phosphan-yl)meth-yl]benzene-1,4-diamine-κ(4)P:P':P'':P'''}tetra-copper(II)]

[4] Alain Collas, et al. (E,E)-N-(2,3,4,5,6-Penta-fluoro-benzyl-idene)-N-(3,4,5-trimeth-oxy-benzyl-idene)benzene-1,4-diamine

[5] Xiao-Ru Pan, et al. N,N,N,N-Tetra-ethyl-6-{2-[(E)-1-(4-nitro-phen-yl)ethyl-idene]hydrazino}-1,3,5-triazine-2,4-diamine

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