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4SC-202

Cat. No. M4868
4SC-202 Structure
Synonym:

domatinostat

Size Price Availability Quantity
10mM*1mL In DMSO USD 130 In stock
5mg USD 120 In stock
10mg USD 180 In stock
50mg USD 540 In stock
100mg USD 900 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 447.51
Formula C23H21N5O3S
CAS Number 910462-43-0
Purity >98%
Solubility DMSO 89 mg/mL;Water <1 mg/mL
Storage at -20°C
References

Preclinical characterization of 4SC-202, a noval isotype specific HDAC inhibitor
S.W.Henning, et,al. 16 - 19 November 2010.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 4SC-202, domatinostat supplier, HDAC, inhibitors

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