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3-Methylpyrazole

Cat. No. M20460
3-Methylpyrazole Structure
Synonym:

3-MP

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Biological Activity

3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase.

Chemical Information
Molecular Weight 82.10
Formula C4H6N2
CAS Number 1453-58-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elizabeth Bester, et al. Bioorg Chem. Coumarin derivatives as inhibitors of d-amino acid oxidase and monoamine oxidase

[2] Kamalon Amrutha, et al. Magn Reson Chem. Interpretation of EPR and optical spectra of Ni(II) ions in crystalline lattices at ambient temperature

[3] Osamu Kurasawa, et al. Bioorg Med Chem. 2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase

[4] Naomi Haruta, et al. Proc Jpn Acad Ser B Phys Biol Sci. Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan

[5] Jairo Quiroga, et al. Acta Crystallogr C. A hydrogen-bonded chain of rings in 5-amino-1-(4-methoxybenzoyl)-3-methylpyrazole and a three-dimensional hydrogen-bonded framework in 5-amino-3-methyl-1-(2-nitrobenzoyl)pyrazole

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Keywords: 3-Methylpyrazole, 3-MP supplier, Dehydrogenase, inhibitors, activators

 
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