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3-Hydroxykynurenine

Cat. No. M15049
3-Hydroxykynurenine Structure
Synonym:

3-Hydroxy-DL-kynurenine

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5mg USD 178  USD178 In stock
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Quality Control & Documentation
Biological Activity

3-Hydroxykynurenine is an active metabolite of tryptophan, it can induce nerve cell apoptosis.

Chemical Information
Molecular Weight 224.21
Formula C10H12N2O4
CAS Number 484-78-6
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cristina C Clement, et al. Nat Commun. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine

[2] Masato Hoshi, et al. Immunohorizons. 3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice

[3] Aleksandr V Zhuravlev, et al. Front Physiol. 3-Hydroxykynurenine in Regulation of Drosophila Behavior: The Novel Mechanisms for Cardinal Phenotype Manifestations

[4] Rossana Canavesi, et al. J Pharm Biomed Anal. Study of Anopheles gambiae 3-hydroxykynurenine transaminase activity and inhibition by LC-MS/MS method

[5] Ana Laura Coln-Gonzlez, et al. Neurotoxicology. 3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the central nervous system

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  Catalog
Abmole Inhibitor Catalog




Keywords: 3-Hydroxykynurenine, 3-Hydroxy-DL-kynurenine supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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