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3-Amino-2-chloroacrolein

Cat. No. M1181
3-Amino-2-chloroacrolein Structure
Size Price Availability Quantity
1 kg USD 1600 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

3-Amino-2-chloroacrolein is an intermediate of COX-2 selective inhibitor Etoricoxib.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 105.52
Formula C3H4ClNO
CAS Number 221615-73-2
Purity >99%
Solubility
Storage at -20°C
Related Etoricoxib Intermediates Products
2-Chloromalonaldehyde

2-Chloromalonaldehyde is an intermediate of COX-2 selective inhibitor Etoricoxib.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 3-Amino-2-chloroacrolein supplier, Etoricoxib Intermediates, inhibitors

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