3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine is an intermediate of selective, irreversible Btk inhibitor Ibrutinib (PCI-32765).
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Molecular Weight | 303.32 |
Formula | C17H13N5O |
CAS Number | 330786-24-8 |
Purity | >98% |
Solubility | |
Storage | at -20°C |
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