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![3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Structure](/upload/structure/Ibrutinib-intermediate(N-2).gif)
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine is an intermediate of selective, irreversible Btk inhibitor Ibrutinib (PCI-32765).
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 303.32 |
| Formula | C17H13N5O |
| CAS Number | 330786-24-8 |
| Purity | >98% |
| Solubility | |
| Storage | at -20°C |
| Related Ibrutinib Intermediates Products |
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| 1-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
1-(4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one is an intermediate of selective, irreversible Btk inhibitor Ibrutinib (PCI-32765). |
| (R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
(R)-3-(4-Phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is an intermediate of selective, irreversible Btk inhibitor Ibrutinib (PCI-32765). |
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