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24-Norursodeoxycholic acid

Cat. No. M21462
24-Norursodeoxycholic acid  Structure
Synonym:

nor-UDCA

Size Price Availability Quantity
5mg USD 350  USD350 In stock
10mg USD 620  USD620 In stock
25mg USD 1000  USD1000 In stock
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Quality Control & Documentation
Biological Activity

24 norursodeoxycholic acid (nor UDCA) is a C23 homologue of UDCA with shortened side chain, which has effective anti cholestasis, anti-inflammatory and anti fibrosis properties.

Chemical Information
Molecular Weight 378.55
Formula C23H38O4
CAS Number 99697-24-2
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alix Bruneau, et al. Curr Opin Gastroenterol. Macrophages in cholangiopathies

[2] Ci Zhu, et al. J Hepatol. 24-Norursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation

[3] Maria Reich, et al. J Hepatol. Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

[4] Olivier Chazouillres. J Hepatol. 24-Norursodeoxycholic acid in patients with primary sclerosing cholangitis: A new "urso saga" on the horizon?

[5] Peter Fickert, et al. Gastroenterology. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

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Keywords: 24-Norursodeoxycholic acid , nor-UDCA supplier, inhibitors, activators


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