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2-Thenoyltrifluoroacetone

Cat. No. M6210
2-Thenoyltrifluoroacetone Structure
Synonym:

TTFA

Size Price Availability Quantity
1g USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In vitro: In contrast to SK-N-BE(2) cells, co-treatment of IMR-32 cells with TTFA not only failed to stimulate formation of ROS produced by cisplatin, but rather suppressed it. This correlates with the attenuation of the caspase-3-like activity in response to combined treatment of IMR-32 cells with TTFA and cisplatin. 

In vivo: TTFA-mediated inhibition of the ubiquinone-binding site of SDHD blocks electron transfer to ubiquinone and may lead to electron-slippage with the formation of superoxide radicals, thereby contributing to ROS production.

Protocol
Cell Experiment
Cell lines NB cell lines
Preparation method For the time lapse, cells were cultivated in the POC-R cell cultivation system at 37 °C and a humidified air/CO2 (5%) atmosphere. Cisplatin ± TTFA was bath-applied before the start of the time lapse and the fluorescence was recorded for 22 h.
Concentrations 75 μM, 100 μM
Incubation time 24 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 222.18
Formula C8H5F3O2S
CAS Number 326-91-0
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy.
Kruspig B, et al. Biochim Biophys Acta. 2016 Aug;1863(8):2065-71. PMID: 27140478.

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
K Kluckova, et al. Cell Death Dis. 2015 May;6(5): e1749. PMID: 25950479.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 2-Thenoyltrifluoroacetone, TTFA supplier, inhibitors

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