Free shipping on all orders over $ 500

2-Phenylethyl isothiocyanate

Cat. No. M9157
2-Phenylethyl isothiocyanate Structure
Synonym:

Isothiocyanic Acid 2-Phenylethyl Ester;2-PE ITC; PEITC

Size Price Availability Quantity
1g USD 40  USD40 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

2-Phenylethyl isothiocyanate is a natural product found in bean sprouts and cruciferous vegetables, and is also an effective antifungal agent, significantly inhibiting spore germination and mycelial growth of Aspergillus intermedius. In addition, 2-Phenylethyl isothiocyanate induces autophagy and inhibits the growth of various tumor cells.

Chemical Information
Molecular Weight 163.24
Formula C9H9NS
CAS Number 2257-09-2
Form Liquid
Solubility (25°C) Soluble in chloroform
ethyl acetate
and dichoromethane
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiao D, et al. Carcinogenesis. Chemopreventive activity of thiol conjugates of isothiocyanates for lung tumorigenesis.

Related Antifungal Products
Stictic Acid

Stictic Acid (Scopularic acid) is a secondary metabolite which can be isolated from a Sumatran lichen Stereocaulon montagneanum. Stictic Acid inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml.

4-Isopropylbenzoic acid

4-Isopropylbenzoic acid is an aromatic monoterpenoid isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid shows antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive mushroom tyrosinase inhibitor.

Cyclo(L-Phe-L-Val)

Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL).

HLF1-11

HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent.

FR179642

FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin.

  Catalog
Abmole Inhibitor Catalog




Keywords: 2-Phenylethyl isothiocyanate, Isothiocyanic Acid 2-Phenylethyl Ester;2-PE ITC; PEITC supplier, Antifungal, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.