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2-Phenylethyl isothiocyanate

Cat. No. M9157
2-Phenylethyl isothiocyanate Structure
Synonym:

Isothiocyanic Acid 2-Phenylethyl Ester

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

2-Phenylethyl isothiocyanate is an NNK-induced lung tumorigenesis inhibitor. Soluble in chloroform, ethyl acetate, and dichoromethane. Insoluble in water.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 163.24
Formula C9H9NS
CAS Number 2257-09-2
Purity >99%
Solubility Soluble in chloroform
ethyl acetate
and dichoromethane
Storage at -20°C
References

Chemopreventive activity of thiol conjugates of isothiocyanates for lung tumorigenesis.
Jiao D, et al. Carcinogenesis. 1997 Nov;18(11):2143-7. PMID: 9395214.

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Keywords: 2-Phenylethyl isothiocyanate, Isothiocyanic Acid 2-Phenylethyl Ester supplier, inhibitors

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