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2-Chloro-5-nitro-benzeneacetic acid

Cat. No. M6208
2-Chloro-5-nitro-benzeneacetic acid Structure
Size Price Availability Quantity
1kg USD 880  USD880 In stock
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Quality Control & Documentation
Biological Activity

Chemical Information
Molecular Weight 215.59
Formula C8H6ClNO4
CAS Number 37777-70-1
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Matthew K Craft, et al. Mechanism of biotin carboxylase inhibition by ethyl 4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulphonylamino]benzoate

[2] Kazuma Gotoh, et al. Crystal structures of four isomeric hydrogen-bonded co-crystals of 6-methyl-quinoline with 2-chloro-4-nitro-benzoic acid, 2-chloro-5-nitro-benzoic acid, 3-chloro-2-nitro-benzoic acid and 4-chloro-2-nitro-benzoic acid

[3] No authors listed. Lodoxamide

[4] B Thimme Gowda, et al. N-(2-Chloro-5-methyl-phen-yl)succinamic acid

[5] Muhammad Nadeem Arshad, et al. 2-Chloro-5-(2-iodo-benzene-sulfonamido)-benzoic acid

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