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2-Aminoethyl diphenylborinate (2-APB)

Cat. No. M9600
2-Aminoethyl diphenylborinate (2-APB) Structure
Synonym:

2-APB

Size Price Availability Quantity
10mM*1mL in DMSO USD 50  USD50 In stock
10mg USD 40  USD40 In stock
25mg USD 60  USD60 In stock
50mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of IP3R, and regulate IP3-induced calcium release. 2-Aminoethyl diphenylborinate (2-APB) inhibits the SOC channel activity and activates TRP channel at higher concentrations.

Chemical Information
Molecular Weight 225.09
Formula C14H16BNO
CAS Number 524-95-8
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mehmet Gazi Boyac, et al. World Neurosurg. Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study

[2] Kenji Takahashi, et al. Exp Cell Res. Molecular Mechanism of 2-APB-induced Ca²⁺ Influx in External Acidification in PC12

[3] Gergely Kovacs, et al. Cell Calcium. Inhibition of the Human Epithelial Calcium Channel TRPV6 by 2-aminoethoxydiphenyl Borate (2-APB)

[4] L Missiaen, et al. Cell Calcium. 2-Aminoethoxydiphenyl Borate Affects the Inositol 1,4,5-trisphosphate Receptor, the Intracellular Ca2+ Pump and the Non-Specific Ca2+ Leak From the Non-Mitochondrial Ca2+ Stores in Permeabilized A7r5 Cells

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Keywords: 2-Aminoethyl diphenylborinate (2-APB), 2-APB supplier, Calcium Channel, inhibitors, activators


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