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2,4-Dichlorophenoxyacetic acid

Cat. No. M9437
2,4-Dichlorophenoxyacetic acid Structure
Size Price Availability Quantity
2g USD 45  USD45 In stock
5g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

2,4-Dichlorophenoxyacetic acid is a plant growth hormone, used as a plant growth regulator.

Chemical Information
Molecular Weight 221.04
Formula C8H6Cl2O3
CAS Number 94-75-7
Form Solid
Solubility (25°C) Ethanol
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sumei Li, et al. Preparation of UiO-66-NH 2 and UiO-66-NH 2/sponge for adsorption of 2,4-dichlorophenoxyacetic acid in water

[2] Przemysław Bernat, et al. 2,4-dichlorophenoxyacetic acid-induced oxidative stress: Metabolome and membrane modifications in Umbelopsis isabellina, a herbicide degrader

[3] Ajit Kumar, et al. Microbial degradation of 2,4-dichlorophenoxyacetic acid: Insight into the enzymes and catabolic genes involved, their regulation and biotechnological implications

[4] Carol J Burns, et al. Review of 2,4-dichlorophenoxyacetic acid (2,4-D) biomonitoring and epidemiology

[5] Lesa L Aylward, et al. Biomonitoring data for 2,4-dichlorophenoxyacetic acid in the United States and Canada: interpretation in a public health risk assessment context using Biomonitoring Equivalents

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