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17α-Methyltestosterone

Cat. No. M6106
17α-Methyltestosterone Structure
Synonym:

Methyltestosterone; 17-Methyltestosterone

Size Price Availability Quantity
100mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

17α-meT is a Class III AAS with an alkylation at C-17 and with restricted potential of metabolizing substrates for aromatization. In fact, 17α-meT cannot be aromatize to 17β-estradiol, the most potent form of mammalian estrogenic steroids, and the main product of aromatase. A single injection of 17α-meT immediately before the footshock produced significant impairment of inhibitory avoidance learning in males but not females. Our results show that exposure to a single pharmacological dose of 17α-meT during periadolescence exerts sex-specific cognitive effects without affecting anxiety.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Gonadally-intact male and female Sprague Dawley rats
Formulation 0.9% saline containing 30% cyclodextrin
Dosages 7.5 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 302.45
Formula C20H30O2
CAS Number 58-18-4
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Synthesis and chemical reactions of the steroidal hormone 17α-methyltestosterone.
El-Desoky el-SI, et al. Steroids. 2016 Jan;105:68-95. PMID: 26639430.

Sex-specific effect of the anabolic steroid, 17α-methyltestosterone, on inhibitory avoidance learning in periadolescent rats.
Ramos-Pratts K, et al. Behav Processes. 2013 Oct;99:73-80. PMID: 23792034.

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Keywords: 17α-Methyltestosterone, Methyltestosterone; 17-Methyltestosterone supplier, Androgen Receptor, inhibitors

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