17α-meT is a Class III AAS with an alkylation at C-17 and with restricted potential of metabolizing substrates for aromatization. In fact, 17α-meT cannot be aromatize to 17β-estradiol, the most potent form of mammalian estrogenic steroids, and the main product of aromatase. A single injection of 17α-meT immediately before the footshock produced significant impairment of inhibitory avoidance learning in males but not females. Our results show that exposure to a single pharmacological dose of 17α-meT during periadolescence exerts sex-specific cognitive effects without affecting anxiety.
|Animal models||Gonadally-intact male and female Sprague Dawley rats|
|Formulation||0.9% saline containing 30% cyclodextrin|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Synthesis and chemical reactions of the steroidal hormone 17α-methyltestosterone.
El-Desoky el-SI, et al. Steroids. 2016 Jan;105:68-95. PMID: 26639430.
Sex-specific effect of the anabolic steroid, 17α-methyltestosterone, on inhibitory avoidance learning in periadolescent rats.
Ramos-Pratts K, et al. Behav Processes. 2013 Oct;99:73-80. PMID: 23792034.
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