Clascoterone (Cortexolone 17α-propionate, CB-03-01) is a new selective androgen receptor (AR) antagonist.
Cell Experiment | |
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Cell lines | PBMC |
Preparation method | Because of the extent of these experiments, the drugs were divided into two groups: dexamethasone, budesonide, beclomethasone dipropionate and fluticasone (first group); and dexamethasone, CsA, FK506 (tacrolimus) and mycophenolate (second group). |
Concentrations | 10^-2 mol/L |
Incubation time | 24 h |
Animal Experiment | |
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Animal models | Female Golden hamsters |
Formulation | 0.05 mL of acetone containing 4 μg of testosterone propionate (TP) |
Dosages | 100−200−400 μg/animal |
Administration | s.c. |
Molecular Weight | 402.52 |
Formula | C24H34O5 |
CAS Number | 19608-29-8 |
Solubility (25°C) | 10 mM in DMSO |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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