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1,4-Dicaffeoylquinic acid

Cat. No. M13559
1,4-Dicaffeoylquinic acid Structure
Synonym:

1,4-DCQA

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Biological Activity

1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production.

Chemical Information
Molecular Weight 516.45
CAS Number 1182-34-9
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Arokia Vijaya Anand Mariadoss, et al. Antioxidants (Basel). Ethyl Acetate Fraction of Helianthus tuberosus L. Induces Anti-Diabetic, and Wound-Healing Activities in Insulin-Resistant Human Liver Cancer and Mouse Fibroblast Cells

[2] Rong-Rong Zhou, et al. Int J Anal Chem. Comparison of the Antioxidant Activities and Phenolic Content of Five Lonicera Flowers by HPLC-DAD/MS-DPPH and Chemometrics

[3] Sae-Rom Yoo, et al. Pharmacogn Mag. Phytochemical Analysis on Quantification and the Inhibitory Effects on Inflammatory Responses from the Fruit of Xanthii fructus

[4] Mitja Krizman, et al. J Pharm Biomed Anal. Determination of phenolic compounds in fennel by HPLC and HPLC-MS using a monolithic reversed-phase column

[5] Michael N Clifford, et al. J Agric Food Chem. Discriminating between the six isomers of dicaffeoylquinic acid by LC-MS(n)

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Keywords: 1,4-Dicaffeoylquinic acid, 1,4-DCQA supplier, TNF Receptor, inhibitors, activators


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