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(R)-(+)-BAY K 8644

Cat. No. M5073
(R)-(+)-BAY K 8644 Structure
Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 200 In stock
50mg USD 800 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ca(2+) sparklets were inhibited by the calcium channel inhibitors R-(+)-Bay K 8644 (1 μM) (0.034 ± 0.02 vs. 0.21 ± 0.08 Hz/mm(2); P<0.05), and diltiazem (10 μM) (0.097 ± 0.04 vs. 0.16 ± 0.06 Hz/mm(2); P<0.05).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 356.3
Formula C16H15F3N2O4
CAS Number 98791-67-4
Purity >99%
Solubility 100 mM in DMSO
Storage at -20°C
References

L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle.
Sidaway P,et.al. PLoS One. 2014 Apr 3. PMID: 24699670.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: (R)-(+)-BAY K 8644 supplier, Calcium Channel, inhibitors

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