Free shipping on all orders over $ 500

(R)-(+)-BAY K 8644

Cat. No. M5073
(R)-(+)-BAY K 8644 Structure

(R)-(+)-Bay-K-8644; R-4407; NI-105; (+)-BAY-K-8644

Size Price Availability Quantity
10mM*1mL In DMSO USD 160 In stock
5mg USD 150 In stock
10mg USD 200 In stock
50mg USD 800 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ca(2+) sparklets were inhibited by the calcium channel inhibitors R-(+)-Bay K 8644 (1 μM) (0.034 ± 0.02 vs. 0.21 ± 0.08 Hz/mm(2); P<0.05), and diltiazem (10 μM) (0.097 ± 0.04 vs. 0.16 ± 0.06 Hz/mm(2); P<0.05).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 356.3
Formula C16H15F3N2O4
CAS Number 98791-67-4
Purity >98%
Solubility 100 mM in DMSO
Storage at -20°C

L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle.
Sidaway P, PLoS One. 2014 Apr 3. PMID: 24699670.

Related Calcium Channel Products
Dantrolene sodium salt

Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant.


Thapsigargin is a potent inhibitor of SERCA ATPase.


Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS.


Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.


L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.

Abmole Inhibitor Catalog 2017

Keywords: (R)-(+)-BAY K 8644, (R)-(+)-Bay-K-8644; R-4407; NI-105; (+)-BAY-K-8644 supplier, Calcium Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.