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RAR/RXR Retinoic acid receptor/Retinoid X receptor


Cat.No.  Name Information
M11052 Bigelovin Bigelovin is a sesquiterpene lactone isolated from sea lilies and is an α agonist of the selective retinoid X receptor α. Bigelovin exerts antitumor activity by inducing apoptosis and autophagy. Bigelovin regulates the mTOR signal path by suppressing the generation of ROS.
M10725 LY2955303 LY2955303 is an effective and selective antagonist of the retinoic acid receptor γ (RARγ). Ki The value is 1.09 nM.
M10507 WYC-209 WYC-209 is a novel inhibitor of tumor-repopulating cells (trcs), inducing trc apoptosis primarily via the caspase 3 pathway.
M9104 HX 531 HX 531 is a potent antagonist of retinoid X receptors (IC50 = 18 nM).
M8764 MM11253 MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARα, RARβ, RXRα).
M8748 UVI3003 UVI3003 is a high-affinity selective Pan-retinoid X receptor (RXR) full antagonist.
M7719 CD437 CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
M6155 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist, it specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.
M5455 Bexarotene Bexarotene (LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
M3973 Tazarotene Tazarotene (AGN 190168) is a new member of the acetylenic class of RARβ/γ selective retinoids which is approved to treat a variety of skin diseases, exhibits an anti-proliferative effect in human basal cell carcinoma (BCC) by triggering caspase-dependent apoptosis.
M3150 Fenretinide Fenretinide (4-HPR) is a synthetic retinoid deriverative. Fenretinide is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
M3094 TTNPB TTNPB (Arotinoid Acid) is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
M2241 Adapalene Adapalene is a third-generation topical retinoid, it is a potent RAR agonist, with AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner.

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