Free shipping on all orders over $ 500

RAR/RXR Retinoic acid receptor/Retinoid X receptor

Inhibitors

Cat.No.  Name Information
M21366 AGN194204 AGN194204 (IRX4204) is inactive against RAR and is an orally active and selective RXR agonist with Kd values of 0.4 nM, 3.6 nM and 3.8 nM for RXRα, RXRβ and RXRγ, respectively, and EC50s of 0.2 nM, 0.8 nM and 0.08 nM. AGN194204 has anti-inflammatory and anti-cancer effects.
M21365 9-cis-Retinoic Acid 9-cis-Retinoic acid (ALRT1057), a derivative of vitamin A, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates the cell cycle and has anticancer, anti-inflammatory and neuroprotective activities.
M14529 Talarozole Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA).
M14528 Palovarotene Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
M14527 Magnolol Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
M14526 Ch55 Ch55 is a potent synthetic retinoid.
M14525 CD3254 CD3254 a potent and selective retinoid-X-receptor (RXR) agonist.
M14524 Tarenflurbil Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM.
M13397 Peretinoin Peretinoin is an oral non-cyclic retinoid with A retinoid structure that targets retinoid nuclear receptors such as RXR and RAR. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with EC50 of 9 μM.
M13345 LE135 LE135 is an effective RAR antagonist, which can selectively bind RARα (Ki is 1.4 μM) and RARβ (Ki is 220 nM), and has a higher affinity for RARβ. The LE135 is highly selective for RARγ, RXRα, RXRβ and RXRγ. LE135 is also a vitamin A acid receptor antagonist.
M11052 Bigelovin Bigelovin is a sesquiterpene lactone isolated from sea lilies and is an α agonist of the selective retinoid X receptor α. Bigelovin exerts antitumor activity by inducing apoptosis and autophagy. Bigelovin regulates the mTOR signal path by suppressing the generation of ROS.
M10725 LY2955303 LY2955303 is an effective and selective antagonist of the retinoic acid receptor γ (RARγ). Ki The value is 1.09 nM.
M10507 WYC-209 WYC-209 is a novel inhibitor of tumor-repopulating cells (trcs), inducing trc apoptosis primarily via the caspase 3 pathway.
M9104 HX 531 HX 531 is a potent antagonist of retinoid X receptors (IC50 = 18 nM).
M8764 MM11253 MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARα, RARβ, RXRα).
M8748 UVI3003 UVI3003 is a high-affinity selective Pan-retinoid X receptor (RXR) full antagonist.
M7719 CD437 CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis.
M6155 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist, it specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.
M5455 Bexarotene Bexarotene (LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
M3973 Tazarotene Tazarotene (AGN 190168) is a new member of the acetylenic class of RARβ/γ selective retinoids which is approved to treat a variety of skin diseases, exhibits an anti-proliferative effect in human basal cell carcinoma (BCC) by triggering caspase-dependent apoptosis.



Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.