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Myosin Myosin


Cat.No.  Name Information
M19970 Aficamten (CK-274) Aficamten (CK-274, CK 3773274) is a novel cardiac myosin inhibitor that reduces myocardial contractile force in vitro and in vivo with an IC50 of 1.4 μM.
M13758 MLCK inhibitor peptide 18 MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations.
M13409 ATM-3507 trihydrochloride ATM-3507 is a potent inhibitor of Tropomyosin with an IC50 value of 3.83-6.84μM in human melanoma cell lines.
M10262 Mavacamten (MYK-461) Mavacamten, also known as SAR-439152 and MYK-461, is the first (first-class) orally bioavailable allosteric and reversible selective inhibitor of Cardiac Myosin. The IC50 of bovine heart and human heart was 490 nM and 711 nM, respectively.
M9636 Blebbistain (±)-Blebbistatin (BLEB) is a small cell permeable selective myosin II inhibitor which potently relaxed normal detrusor smooth muscle.
M7624 2,3-Butanedione monoxime 2,3-Butanedione Monoxime (BDM) is a myosin ATPASE inhibitor. 2,3-Butanedione Monoxime is a skeletal and cardiac muscle contraction inhibitor. 2,3-Butanedione monoxime induces sarcoplasmic reticulum Ca2+ release.
M2459 Blebbistatin Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. *The compound is unstable in solutions, freshly prepared is recommended
M2004 Omecamtiv mecarbil Omecamtiv mecarbil (CK-1827452), a specific cardiac myosin agonist, is a clinical compound used in left ventricular systolic heart failure.

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