Certificate of Analysis

 

Product Name: Verubecestat (MK-8931)
Catalog Number: M9386
CAS Number: 1286770-55-5

Physical and Chemical Properties
Formula: C17H17F2N5O3S
Molecular Weight: 409.41
Solubility: DMSO ≥ 30 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Verubecestat (MK-8931) Structure
Analytical Data
QC Standard: 98.8%
H-NMR: Consistent with structure
Product Information
Description: Verubecestat (MK-8931) is an orally active, high-affinity (beta-secretase 1) BACE1 and BACE2 inhibitor, with Ki values of 2.2 nM and 0.38 nM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.