Certificate of Analysis


Catalog Number: M6044
Product Name: Uprosertib (GSK2141795)
CAS Number: 1047634-65-0

Physical and Chemical Properties
Formula: C18H16Cl2F2N4O2
Molecular Weight: 429.25
Solubility: 36 mg/mL in DMSO
Long-term Storage: at -20°C
Chemical Structure: Uprosertib (GSK2141795) Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: GSK2141795 is a potent and selective pan-Akt inhibitor with IC50 values of 180 nM for Akt1, 328 nM for Akt2, and 38 nM for Akt3 respectively (Clinical phase 1).
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.