Certificate of Analysis


Catalog Number: M6186
Product Name: TPX-0005
CAS Number: 1802220-02-5

Physical and Chemical Properties
Formula: C18H18FN5O2
Molecular Weight: 355.37
Solubility: 83.3 mg/mL
Storage: at -20°C
Chemical Structure: TPX-0005 Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.