Certificate of Analysis

 

Product Name: Repotrectinib (TPX-0005)
Catalog Number: M6186
CAS Number: 1802220-02-5

Physical and Chemical Properties
Formula: C18H18FN5O2
Molecular Weight: 355.37
Solubility: 83 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Repotrectinib (TPX-0005) Structure
Analytical Data
QC Standard: 99.85%
H-NMR: Consistent with structure
Product Information
Description: Repotrectinib (TPX-0005) is a potential best-in-class ALK/ROS1/TRK inhibitor against SRC, wild-type WT ALK, The IC50 values of ALK G1202R and ALK L1196M were 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.