Certificate of Analysis

 

Catalog Number: M2982
Product Name: Ro 31-8220 Mesylate
CAS Number: 138489-18-6

Physical and Chemical Properties
Formula: C25H23N5O2S.CH4O3S
Molecular Weight: 553.65
Solubility: DMSO 90 mg/mL
Long-term Storage: at -20℃
Chemical Structure: Ro 31-8220 Mesylate Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively, and also shows potent inhibition against MAPKAP-K1b, MSK1, GSK3β and S6K1.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.