Certificate of Analysis

 

Catalog Number: M3737
Product Name: Pyridone 6
CAS Number: 457081-03-7

Physical and Chemical Properties
Formula: C18H16FN3O
Molecular Weight: 309.34
Solubility: DMSO 5 mg/mL
Long-term Storage: at -20℃
Chemical Structure: Pyridone 6 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Pyridone 6 is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk 2 (IC50 = 1 nM) (Janus protein tyrosine kinases).
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.