Certificate of Analysis

 

Catalog Number: M1765
Product Name: PF-2341066
CAS Number: 877399-52-5

Physical and Chemical Properties
Formula: C21H22Cl2FN5O
Molecular Weight: 450.34
Solubility: DMSO ≥23 mg/mL
Long-term Storage: at -20℃
Chemical Structure: PF-2341066 Structure
Analytical Data
HPLC: Shows Min 98.62% purity
H-NMR: Consistent with structure
Product Information
Description: PF-2341066 (Crizotinib) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.