Certificate of Analysis

 

Catalog Number: M5873
Product Name: Pexmetinib (ARRY-614)
CAS Number: 945614-12-0

Physical and Chemical Properties
Formula: C31H33FN6O3
Molecular Weight: 556.63
Solubility: 100 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: Pexmetinib (ARRY-614) Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.