Certificate of Analysis

 

Catalog Number: M5275
Product Name: Nazartinib
CAS Number: 1508250-71-2

Physical and Chemical Properties
Formula: C26H31ClN6O2
Molecular Weight: 495.02
Solubility: 99 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: Nazartinib Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.