Certificate of Analysis

 

Catalog Number: M5276
Product Name: MK-8617
CAS Number: 1187990-87-9

Physical and Chemical Properties
Formula: C24H21N5O4
Molecular Weight: 443.45
Solubility: 88 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: MK-8617 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.