Certificate of Analysis

 

Catalog Number: M3516
Product Name: MK-5108
CAS Number: 1010085-13-8

Physical and Chemical Properties
Formula: C22H21ClFN3O3S
Molecular Weight: 461.94
Solubility: DMSO 90 mg/mL
Long-term Storage: at -20℃
Chemical Structure: MK-5108 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.