Certificate of Analysis

 

Product Name: Ribociclib succinate (LEE011 succinate)
Catalog Number: M4889
CAS Number: 1374639-75-4

Physical and Chemical Properties
Formula: C27H36N8O5
Molecular Weight: 552.63
Solubility: DMSO ≥ 30 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Ribociclib succinate (LEE011 succinate) Structure
Analytical Data
QC Standard: 99.57%
H-NMR: Consistent with structure
Product Information
Description: Ribociclib succinate (LEE011 succinate) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.