Certificate of Analysis

 

Product Name: LDN-193189 dihydrochloride
Catalog Number: M2805
CAS Number: 1435934-00-1

Physical and Chemical Properties
Formula: C25H24Cl2N6
Molecular Weight: 479.40
Solubility: Water 11 mg/mL; DMSO 8 mg/mL (ultrasonic and warming)
Storage: 4°C, dry, sealed
Chemical Structure: LDN-193189 dihydrochloride Structure
Analytical Data
QC Standard: 100.00%
H-NMR: Consistent with structure
Product Information
Description: LDN-193189 dihydrochloride is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, 200-fold selectivity for BMP versus TGF-β.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.