Certificate of Analysis

 

Product Name: Ceritinib (LDK378) dihydrochloride
Catalog Number: M6168
CAS Number: 1380575-43-8

Physical and Chemical Properties
Formula: C28H38Cl3N5O3S
Molecular Weight: 631.06
Solubility: Water ≥ 100 mg/mL; DMSO ≥ 60 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Ceritinib (LDK378) dihydrochloride Structure
Analytical Data
QC Standard: 99.81%
H-NMR: Consistent with structure
Product Information
Description: Ceritinib dihydrochloride (LDK378 dihydrochloride) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.