Certificate of Analysis


Catalog Number: M6168
Product Name: LDK378 dihydrochloride
CAS Number: 1380575-43-8

Physical and Chemical Properties
Formula: C28H38Cl3N5O3S
Molecular Weight: 631.06
Solubility: 170 mg/mL in water
Storage: at -20°C
Chemical Structure: LDK378 dihydrochloride Structure
Analytical Data
HPLC: Shows Min 99.81% purity
H-NMR: Consistent with structure
Product Information
Description: LDK378 2Hcl (Ceritinib) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.