Certificate of Analysis

 

Catalog Number: M6168
Product Name: LDK378 dihydrochloride
CAS Number: 1380575-43-8

Physical and Chemical Properties
Formula: C28H38Cl3N5O3S
Molecular Weight: 631.06
Solubility: 170 mg/mL in water
Long-term Storage: at -20℃
Chemical Structure: LDK378 dihydrochloride Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: LDK378 2Hcl (Ceritinib) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.