Certificate of Analysis


Catalog Number: M1787
Product Name: INCB18424
CAS Number: 941678-49-5

Physical and Chemical Properties
Formula: C17H18N6
Molecular Weight: 306.37
Solubility: DMSO 60 mg/mL
Storage: at -20°C
Chemical Structure: INCB18424 Structure
Analytical Data
HPLC: Shows Min 99.35% purity
H-NMR: Consistent with structure
Product Information
Description: INCB18424 is a potent inhibitor of both JAK1 and JAK2 with selectivity versus JAK3 and TYK2 (IC50 values of 2.7, 4.5, 332, and 19 nM, respectively, in biochemical assays).
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.