Certificate of Analysis

 

Catalog Number: M5269
Product Name: GSK180736A
CAS Number: 817194-38-0

Physical and Chemical Properties
Formula: C19H16FN5O2
Molecular Weight: 365.36
Solubility: 73 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: GSK180736A Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.