Certificate of Analysis

 

Product Name: GSK-J4 hydrochloride
Catalog Number: M2731
CAS Number: 1797983-09-5

Physical and Chemical Properties
Formula: C24H27N5O2.HCl
Molecular Weight: 453.96
Solubility: DMSO 50 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: GSK-J4 hydrochloride Structure
Analytical Data
QC Standard: 98.95%
H-NMR: Consistent with structure
Product Information
Description: GSK J4 hydrochloride is a cell permeable procompound of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.