Certificate of Analysis

 

Product Name: Gefitinib
Catalog Number: M1749
CAS Number: 184475-35-2

Physical and Chemical Properties
Formula: C22H24ClFN4O3
Molecular Weight: 446.90
Solubility: DMSO 68 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Gefitinib Structure
Analytical Data
QC Standard: 99.97%
H-NMR: Consistent with structure
Product Information
Description: Gefitinib (ZD1839) is an EGFR tyrosine kinase and Akt phosphorylation inhibitor. Gefitinib significantly down-regulates CD47 expression and increases DC phagocytosis in non-small cell lung cancer cells such as PC9, H1437 and H1573. Gefitinib combined with CD47 antibody can enhance the phagocytosis of macrophages.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.