Certificate of Analysis


Catalog Number: M5613
Product Name: Entrectinib (RXDX-101)
CAS Number: 1108743-60-7

Physical and Chemical Properties
Formula: C31H34F2N6O2
Molecular Weight: 560.64
Solubility: 100 mg/mL in DMSO
Storage: at -20°C
Chemical Structure: Entrectinib (RXDX-101) Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Phase 2.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.